Элейн Фукс

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Элейн Фукс

Elaine Fuchs
CampaignFuchs.JPG
Дата рождения 1940
Место рождения Чикаго, США













Президент Обама и Элейн Фукс.

Элейн Фукс (англ. Elaine Fuchs) — американский биолог, Ph.D, профессор Лаборатории клеточной биологии млекопитающих и развития Медицинского института Говарда Хьюза, профессор Рокфеллерского университета, химик, биохимик, биолог клетки[1].

[править] Биография

Элейн Фукс родилась в 1940 году в семье учёных.

В 1972 году получила степень бакалавра в области химии в университете Иллинойса.

Как и многие обманутые левой пропагандой протестовала против войны во Вьетнаме.

Получила степень доктора философии в биохимии в Принстонском университете.

В 2001 году — президент Американского общества клеточной биологии.

С 2002 года — профессор Университета Рокфеллера, руководитель лаборатории клеточной биологии млекопитающих университета Рокфеллера).

Сделала несколько открытий в биологии стволовых клеток кожи и волос.

В 2003 году сообщила об открытии двух белков, которые руководят работой стволовых клеток, для того, чтобы те становились волосяными фолликулами, а не кожей.

Разработала новые методы и технику для отслеживания и изоляции стволовых клеток, дифференцирующихся в клетки кожи и волос.

[править] Труды

  1. Beronja S, Janki P, Heller E, Lien WH, Keyes BE, Oshimori N, Fuchs E. "RNAi screens in mice identify physiological regulators of oncogenic growth." Nature 501(7466):185-90 (2013).
  2. Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E. "NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche." Nature 495(7439):98-102 (2013).
  3. Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E. "Sweat glands grown from newly identified stem cells." Cell 150(1):136-150 (2012).
  4. Fuchs E. "The impact of cell culture on stem cell research." Cell Stem Cell 10(6):640-1 (2012).
  5. Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E. "An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration." Nature 485(7396):104-8 (2012).
  6. Oshimori N, Fuchs E. "Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation." Cell Stem Cell 10(1):63-75 (2012).
  7. Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E. "Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage." Cell Stem Cell 9(3):219-32 (2011) .
  8. Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E. "A role for the primary cilium in Notch signaling and epidermal differentiation during skin development." Cell 145(7):1129-41 (2011).
  9. Schober M, Fuchs E. "Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling." Proc Natl Acad Sci U S A 108(26):10544-9 (2011).
  10. Fuchs E. "Reflections of an ISSCR president, 2010-2011." Cell Stem Cell 8(6):629-30 (2011).
  11. Zhang L, Stokes N, Polak L, Fuchs E. "Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment." Cell Stem Cell 8(3):294-308 (2011).
  12. Luxenburg C, Amalia Pasolli H, Williams SE, Fuchs E. "Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation." Nat Cell Biol 13(3):203-14 (2011).
  13. Williams SE, Beronja S, Pasolli HA, Fuchs E. "Asymmetric cell divisions promote Notch-dependent epidermal differentiation." Nature 470(7334):353-8 (2011).
  14. Wu X, Shen QT, Oristian DS, Lu CP, Zheng Q, Wang HW, Fuchs E. "Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β." Cell 144(3):341-52 (2011).
  15. Hsu YC, Pasolli HA, Fuchs E. "Dynamics between stem cells, niche, and progeny in the hair follicle." Cell 144(1):92-105 (2011).
  16. Ezhkova E, Fuchs E."Regenerative medicine: An eye to treating blindness." Nature 466(7306):567-8 (2010).
  17. Beronja S, Livshits G, Williams S, Fuchs E. "Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos." Nat Med 16(7):821-7 (2010).
  18. Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E. "Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia." Nat Genet 41(10):1068-1075 (2009).
  19. Fuchs E. "Building confidence:the transition from student to professor." Nat Cell Biol 11(7):786 (2009).
  20. Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. "Cyfip1 is a putative invasion suppressor in epithelial cancers." Cell 137(6):1047-61 (2009).
  21. Fuchs E. "The tortoise and the hair: slow-cycling cells in the stem cell race." Cell 137(5):811-9 (2009).
  22. Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E. "Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells." Cell 136(6):1122-35 (2009).
  23. Blanpain C, Fuchs E. "Epidermal homeostasis: a balancing act of stem cells in the skin." Nat Rev Mol Cell Biol 10(3):207-17 (2009).
  24. Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. "A two-step mechanism for stem cell activation during hair regeneration." Cell Stem Cell 4(2):155-69 (2009).
  25. Wu X, Kodama A, Fuchs E. "ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity." Cell 135(1):137-48 (2008).
  26. Devenport D, Fuchs E. "Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles." Nat Cell Biol 10(11):1257-68 (2008).
  27. Nowak JA, Polak L, Pasolli HA, Fuchs E. "Hair follicle stem cells are specified and function in early skin morphogenesis." Cell Stem Cell. 3(1):33-43 (2008).
  28. Yi R, Poy MN, Stoffel M, Fuchs E. "A skin microRNA promotes differentiation by repressing 'stemness'." Nature 452(7184): 225-9 (2008).
  29. Horsley V, Aliprantis AO, Polak L, Glimcher LH, and Fuchs E. "NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells." Cell 132: 299-310, (2008).
  30. Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. "Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia." Cancer Cell. 12(4):313-27 (2007).
  31. Schober M, Raghavan S, Nikolova M, Polak L, Pasolli HA, Beggs HE, Reichardt LF, Fuchs E. "Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics." J Cell Biol 176: 667-680 (2007).
  32. Fuchs E. "Scratching the surface of skin development." Nature 445: 834-842 (2007).
  33. Li J, Greco V, Guasch G, Fuchs E, Mombaerts P. "Mice cloned from skin cells." Proc Natl Acad Sci U S A 104: 2738-2743 (2007).
  34. Nguyen H, Rendl M, Fuchs E. "Tcf3 governs stem cell features and represses cell fate determination in the skin." Cell 127: 171-183 (2006).
  35. Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, and Fuchs E. "Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland." Cell 126(3):597-609 (2006).
  36. Rhee H, Polak L, and Fuchs E. "Lhx2 maintains stem cell character in hair follicles." Science 312:1946-9 (2006).
  37. Perez-Moreno M., Davis MA, Wong E, Pasolli HA, Reynolds AB, and Fuchs E. "p120-catenin mediates inflammatory responses in the skin." Cell 124: 631-44 (2006).
  38. Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, and Fuchs E. "Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs." Nat Genet 38: 356-62 (2006).
  39. Rendl M, Lewis L, and Fuchs E. "Molecular dissection of mesenchymal-epithelial interactions in the hair follicle." PLoS Biol 3: 1910-23 (2005).
  40. Lechler T and Fuchs E. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin." Nature 437: 275-280 (2005).
  41. Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. "A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis." PLoS Biol 3: 131-143 (2005).
  42. Blanpain C, Lowry WE, Geoghegan A, Polak L. and Fuchs E. "Self renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche." Cell 118: 635-648 (2004).
  43. Fuchs E, Tumbar T, and Guasch G. "Socializing with the neighbors: stem cells and their niches." Cell 116: 769-778 (2004).
  44. TumbarT, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E. "Defining the epithelial stem cell niche of the skin." Science 303: 359-363 (2004).
  45. Merrill BJ, Pasolli HA, Polak L, Rendl M, Garcia-Garcia MJ, Anderson K, and Fuchs E. "Tcf3: A transcriptional regulator of axis induction in the early embryo." Development 131: 263-274 (2004).
  46. Kobielak K, Pasolli HA, Alonso L, Polak L, and Fuchs E. "Defining BMP functions in the hair follicle by conditional ablation of BMP Receptor IA." J Cell Biol 163: 609-624 (2003).
  47. Kodama A, Karakesisoglou I, Wong E, Polak L, and Fuchs E. "ACF7: An essential integrator of microtubule dynamics." Cell 115: 343-354 (2003).
  48. Kaufman CK, Pasolli HA, Rendl M, Bolotin D, Lim KC,Dai X, Alegre ML, and Fuchs E."GATA-3: An unexpected regulator of cell lineage determination in skin." Genes Dev 17: 2108-2122 (2003).
  49. Perez-Moreno M, Jamora C, and Fuchs E. "Sticky business: orchestrating cellular signals at adherens junctions." Cell 112: 535-48 (2003).
  50. Vaezi A, Bauer C, Vasioukhin V, and Fuchs E. "Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in assembling a stratified epithelium." Dev Cell 3: 367-381 (2002).
  51. Merrill BJ, Gat U, DasGupta R and Fuchs E. "Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin." Genes Dev 15: 1688-1705 (2001).
  52. Vasioukhin V, Bauer C, Degenstein L, Wise B, and Fuchs E. "Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin." Cell 104: 605-617 (2001).
  53. Vasioukhin V, Bowers E, Bauer C, Degenstein L, and Fuchs E. "Desmoplakin plays an essential role in epidermal sheet formation." Nat Cell Biol 3: 1076-1085 (2001).
  54. Raghavan S, Bauer C, Mundschau G, Li Q, and Fuchs E. "Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination." J Cell Biol 150: 1149-60 (2000).
  55. Vasioukhin V, Bauer C, Yin M, and Fuchs E. "Directed actin polymerization is the driving force for epithelial cell-cell adhesion." Cell 100: 209-219 (2000).
  56. Chan EF, Gat U, McNiff JM, and Fuchs, E. "A common human skin tumour is caused by activating mutations in beta-catenin." Nat Genet 21: 410-3 (1999).
  57. DasGupta R and Fuchs E. "Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation." Development 126: 4557-68 (1999).
  58. Yang Y, Bauer C, Strasser G, Wollman R, Julien JP and Fuchs E. "Integrators of the cytoskeleton that stabilize microtubules." Cell 98: 229-38 (1999).
  59. Gat U, DasGupta R, Degenstein L, and Fuchs E. "De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in Skin." Cell 95: 605-614 (1998).
  60. Fuchs E and Cleveland D. "Structural scaffolding of IFs in health and disease." Science 279: 514-519 (1998).
  61. Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW and Fuchs E. "An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments." Cell 86: 655-65 (1996).
  62. Guo L, Degenstein L, Dowling J, Yu QC, Wollmann R, Perman B and Fuchs E. "Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration." Cell 81: 233-43 (1995).
  63. Paller AS, Syder AJ, Chan YM, Yu QC, Hutton E, Tadini G, and Fuchs E. "Genetic and clinical mosaicism in a type of epidermal nevus." N Engl J Med 331: 1408-15 (1994).
  64. Cheng J, Syder AJ, Yu Q-C, Letai A, Paller AS, and Fuchs E. "The genetic basis of EH, a disorder of differentiation-specific epidermal keratin genes." Cell 70:811-819 (1992).
  65. Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS and Fuchs E. "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses." Cell 66:1301-11 (1991).
  66. Vassar R, Coulombe PA, Degenstein L, Albers K and Fuch E. "Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease." Cell 64: 365-80 (1991).
  67. Hanukoglu I and Fuchs E. "The cDNA sequence of type II cytoskeletal keratin reveals constant and variable structural domains among keratins." Cell 33:915-924 (1983).
  68. Hanukoglu I. and Fuchs E. "The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins." Cell 31:243-52 (1982).
  69. Fuchs EV, Coppock SM, Green H and Cleveland DW. "Two distinct classes of keratin genes and their evolutionary significance." Cell 27:75-84 (1981).
  70. Fuchs E and Green H. "Regulation of differentiation of keratinocytes by vitamin A." Cell 25:617-625 (1981).
  71. Fuchs E and Green H. "Changes in keratin gene expression during terminal differentiation." Cell 19:1033-1042 (1980).
  72. Fuchs E and Green H. "Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules." Cell 17:573-582 (1979).
  73. Fuchs E and Green H. "Expression of keratin genes in epidermis and cultured epidermal cells." Cell 15:887-897 (1978).

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