Элейн Фукс
Элейн Фукс (англ. Elaine Fuchs) — американский биолог, Ph.D, профессор Лаборатории клеточной биологии млекопитающих и развития Медицинского института Говарда Хьюза, профессор Рокфеллерского университета, химик, биохимик, биолог клетки[1].
Биография[править]
Элейн Фукс родилась в 1940 году в семье учёных.
В 1972 году получила степень бакалавра в области химии в университете Иллинойса.
Как и многие обманутые левой пропагандой протестовала против войны во Вьетнаме.
Получила степень доктора философии в биохимии в Принстонском университете.
В 2001 году — президент Американского общества клеточной биологии.
С 2002 года — профессор Университета Рокфеллера, руководитель лаборатории клеточной биологии млекопитающих университета Рокфеллера).
Сделала несколько открытий в биологии стволовых клеток кожи и волос.
В 2003 году сообщила об открытии двух белков, которые руководят работой стволовых клеток, для того, чтобы те становились волосяными фолликулами, а не кожей.
Разработала новые методы и технику для отслеживания и изоляции стволовых клеток, дифференцирующихся в клетки кожи и волос.
Труды[править]
- Beronja S, Janki P, Heller E, Lien WH, Keyes BE, Oshimori N, Fuchs E. "RNAi screens in mice identify physiological regulators of oncogenic growth." Nature 501(7466):185-90 (2013).
- Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E. "NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche." Nature 495(7439):98-102 (2013).
- Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E. "Sweat glands grown from newly identified stem cells." Cell 150(1):136-150 (2012).
- Fuchs E. "The impact of cell culture on stem cell research." Cell Stem Cell 10(6):640-1 (2012).
- Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E. "An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration." Nature 485(7396):104-8 (2012).
- Oshimori N, Fuchs E. "Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation." Cell Stem Cell 10(1):63-75 (2012).
- Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E. "Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage." Cell Stem Cell 9(3):219-32 (2011) .
- Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E. "A role for the primary cilium in Notch signaling and epidermal differentiation during skin development." Cell 145(7):1129-41 (2011).
- Schober M, Fuchs E. "Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling." Proc Natl Acad Sci U S A 108(26):10544-9 (2011).
- Fuchs E. "Reflections of an ISSCR president, 2010-2011." Cell Stem Cell 8(6):629-30 (2011).
- Zhang L, Stokes N, Polak L, Fuchs E. "Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment." Cell Stem Cell 8(3):294-308 (2011).
- Luxenburg C, Amalia Pasolli H, Williams SE, Fuchs E. "Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation." Nat Cell Biol 13(3):203-14 (2011).
- Williams SE, Beronja S, Pasolli HA, Fuchs E. "Asymmetric cell divisions promote Notch-dependent epidermal differentiation." Nature 470(7334):353-8 (2011).
- Wu X, Shen QT, Oristian DS, Lu CP, Zheng Q, Wang HW, Fuchs E. "Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β." Cell 144(3):341-52 (2011).
- Hsu YC, Pasolli HA, Fuchs E. "Dynamics between stem cells, niche, and progeny in the hair follicle." Cell 144(1):92-105 (2011).
- Ezhkova E, Fuchs E."Regenerative medicine: An eye to treating blindness." Nature 466(7306):567-8 (2010).
- Beronja S, Livshits G, Williams S, Fuchs E. "Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos." Nat Med 16(7):821-7 (2010).
- Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E. "Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia." Nat Genet 41(10):1068-1075 (2009).
- Fuchs E. "Building confidence:the transition from student to professor." Nat Cell Biol 11(7):786 (2009).
- Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. "Cyfip1 is a putative invasion suppressor in epithelial cancers." Cell 137(6):1047-61 (2009).
- Fuchs E. "The tortoise and the hair: slow-cycling cells in the stem cell race." Cell 137(5):811-9 (2009).
- Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E. "Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells." Cell 136(6):1122-35 (2009).
- Blanpain C, Fuchs E. "Epidermal homeostasis: a balancing act of stem cells in the skin." Nat Rev Mol Cell Biol 10(3):207-17 (2009).
- Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. "A two-step mechanism for stem cell activation during hair regeneration." Cell Stem Cell 4(2):155-69 (2009).
- Wu X, Kodama A, Fuchs E. "ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity." Cell 135(1):137-48 (2008).
- Devenport D, Fuchs E. "Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles." Nat Cell Biol 10(11):1257-68 (2008).
- Nowak JA, Polak L, Pasolli HA, Fuchs E. "Hair follicle stem cells are specified and function in early skin morphogenesis." Cell Stem Cell. 3(1):33-43 (2008).
- Yi R, Poy MN, Stoffel M, Fuchs E. "A skin microRNA promotes differentiation by repressing 'stemness'." Nature 452(7184): 225-9 (2008).
- Horsley V, Aliprantis AO, Polak L, Glimcher LH, and Fuchs E. "NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells." Cell 132: 299-310, (2008).
- Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. "Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia." Cancer Cell. 12(4):313-27 (2007).
- Schober M, Raghavan S, Nikolova M, Polak L, Pasolli HA, Beggs HE, Reichardt LF, Fuchs E. "Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics." J Cell Biol 176: 667-680 (2007).
- Fuchs E. "Scratching the surface of skin development." Nature 445: 834-842 (2007).
- Li J, Greco V, Guasch G, Fuchs E, Mombaerts P. "Mice cloned from skin cells." Proc Natl Acad Sci U S A 104: 2738-2743 (2007).
- Nguyen H, Rendl M, Fuchs E. "Tcf3 governs stem cell features and represses cell fate determination in the skin." Cell 127: 171-183 (2006).
- Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, and Fuchs E. "Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland." Cell 126(3):597-609 (2006).
- Rhee H, Polak L, and Fuchs E. "Lhx2 maintains stem cell character in hair follicles." Science 312:1946-9 (2006).
- Perez-Moreno M., Davis MA, Wong E, Pasolli HA, Reynolds AB, and Fuchs E. "p120-catenin mediates inflammatory responses in the skin." Cell 124: 631-44 (2006).
- Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, and Fuchs E. "Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs." Nat Genet 38: 356-62 (2006).
- Rendl M, Lewis L, and Fuchs E. "Molecular dissection of mesenchymal-epithelial interactions in the hair follicle." PLoS Biol 3: 1910-23 (2005).
- Lechler T and Fuchs E. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin." Nature 437: 275-280 (2005).
- Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. "A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis." PLoS Biol 3: 131-143 (2005).
- Blanpain C, Lowry WE, Geoghegan A, Polak L. and Fuchs E. "Self renewal, multipotency and the existence of two cell populations within an epithelial stem cell niche." Cell 118: 635-648 (2004).
- Fuchs E, Tumbar T, and Guasch G. "Socializing with the neighbors: stem cells and their niches." Cell 116: 769-778 (2004).
- TumbarT, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M and Fuchs E. "Defining the epithelial stem cell niche of the skin." Science 303: 359-363 (2004).
- Merrill BJ, Pasolli HA, Polak L, Rendl M, Garcia-Garcia MJ, Anderson K, and Fuchs E. "Tcf3: A transcriptional regulator of axis induction in the early embryo." Development 131: 263-274 (2004).
- Kobielak K, Pasolli HA, Alonso L, Polak L, and Fuchs E. "Defining BMP functions in the hair follicle by conditional ablation of BMP Receptor IA." J Cell Biol 163: 609-624 (2003).
- Kodama A, Karakesisoglou I, Wong E, Polak L, and Fuchs E. "ACF7: An essential integrator of microtubule dynamics." Cell 115: 343-354 (2003).
- Kaufman CK, Pasolli HA, Rendl M, Bolotin D, Lim KC,Dai X, Alegre ML, and Fuchs E."GATA-3: An unexpected regulator of cell lineage determination in skin." Genes Dev 17: 2108-2122 (2003).
- Perez-Moreno M, Jamora C, and Fuchs E. "Sticky business: orchestrating cellular signals at adherens junctions." Cell 112: 535-48 (2003).
- Vaezi A, Bauer C, Vasioukhin V, and Fuchs E. "Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in assembling a stratified epithelium." Dev Cell 3: 367-381 (2002).
- Merrill BJ, Gat U, DasGupta R and Fuchs E. "Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin." Genes Dev 15: 1688-1705 (2001).
- Vasioukhin V, Bauer C, Degenstein L, Wise B, and Fuchs E. "Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin." Cell 104: 605-617 (2001).
- Vasioukhin V, Bowers E, Bauer C, Degenstein L, and Fuchs E. "Desmoplakin plays an essential role in epidermal sheet formation." Nat Cell Biol 3: 1076-1085 (2001).
- Raghavan S, Bauer C, Mundschau G, Li Q, and Fuchs E. "Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination." J Cell Biol 150: 1149-60 (2000).
- Vasioukhin V, Bauer C, Yin M, and Fuchs E. "Directed actin polymerization is the driving force for epithelial cell-cell adhesion." Cell 100: 209-219 (2000).
- Chan EF, Gat U, McNiff JM, and Fuchs, E. "A common human skin tumour is caused by activating mutations in beta-catenin." Nat Genet 21: 410-3 (1999).
- DasGupta R and Fuchs E. "Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation." Development 126: 4557-68 (1999).
- Yang Y, Bauer C, Strasser G, Wollman R, Julien JP and Fuchs E. "Integrators of the cytoskeleton that stabilize microtubules." Cell 98: 229-38 (1999).
- Gat U, DasGupta R, Degenstein L, and Fuchs E. "De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in Skin." Cell 95: 605-614 (1998).
- Fuchs E and Cleveland D. "Structural scaffolding of IFs in health and disease." Science 279: 514-519 (1998).
- Yang Y, Dowling J, Yu QC, Kouklis P, Cleveland DW and Fuchs E. "An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments." Cell 86: 655-65 (1996).
- Guo L, Degenstein L, Dowling J, Yu QC, Wollmann R, Perman B and Fuchs E. "Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration." Cell 81: 233-43 (1995).
- Paller AS, Syder AJ, Chan YM, Yu QC, Hutton E, Tadini G, and Fuchs E. "Genetic and clinical mosaicism in a type of epidermal nevus." N Engl J Med 331: 1408-15 (1994).
- Cheng J, Syder AJ, Yu Q-C, Letai A, Paller AS, and Fuchs E. "The genetic basis of EH, a disorder of differentiation-specific epidermal keratin genes." Cell 70:811-819 (1992).
- Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS and Fuchs E. "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses." Cell 66:1301-11 (1991).
- Vassar R, Coulombe PA, Degenstein L, Albers K and Fuch E. "Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease." Cell 64: 365-80 (1991).
- Hanukoglu I and Fuchs E. "The cDNA sequence of type II cytoskeletal keratin reveals constant and variable structural domains among keratins." Cell 33:915-924 (1983).
- Hanukoglu I. and Fuchs E. "The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins." Cell 31:243-52 (1982).
- Fuchs EV, Coppock SM, Green H and Cleveland DW. "Two distinct classes of keratin genes and their evolutionary significance." Cell 27:75-84 (1981).
- Fuchs E and Green H. "Regulation of differentiation of keratinocytes by vitamin A." Cell 25:617-625 (1981).
- Fuchs E and Green H. "Changes in keratin gene expression during terminal differentiation." Cell 19:1033-1042 (1980).
- Fuchs E and Green H. "Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules." Cell 17:573-582 (1979).
- Fuchs E and Green H. "Expression of keratin genes in epidermis and cultured epidermal cells." Cell 15:887-897 (1978).
Примечания[править]
- Родившиеся в 1940 году
- Персоналии по алфавиту
- Родившиеся в Чикаго
- Учёные по алфавиту
- Выпускники Иллинойсского университета
- Преподаватели Чикагского университета
- Выпускники Принстонского университета
- Члены и члены-корреспонденты Национальной академии наук США
- Члены Американской академии искусств и наук
- Публицисты
- Цитологи
- Биологи США
- Женщины-биологи
- Ашкеназы
- Евреи в США
- Евреи-биологи